Compatibilité du soluté Plasmalyte-A MD avec plusieurs autres médicaments pour une administration en Y
Mots-clés :
Administration en Y, Plasmalyte-A, compatibilitéRésumé
Objective: To establish the compatibility of the Plasmalyte-A ® solution with 99 other drugs when administered in Y.
Method: Plasmalyte-A MD was combined (1: 1 ratio) sequentially with 99 undiluted injectable drugs at room temperature. Each preparation was carried out twice. The first underwent visual evaluation and a light blocking particle count test immediately after mixing. These tests were repeated four hours after the initial mixing using the second preparation. To be considered compatible, the mixtures must not exhibit precipitation or any other observable change (turbidity, crystals, gas formation, color change) and must meet the specification established by USP <788> 1.B, at both at time zero and four hours after mixing.
Results: A total of 87 of the 99 injectable drugs tested with Plasmalyte-A MD were found to be compatible both visually with the naked eye and using the particle counter according to USP <788>.
Conclusion: A number of drugs have been shown to be compatible when mixed at a 1: 1 ratio with Plasmalyte-AMD. However, it should be taken into account that only the physical criteria were evaluated in this study.
Abstract
Objective: To determine the compatibility of Plasmalyte-A® with 99 other drugs during Y-site administration.
Method: Plasmalyte-A® was combined (1: 1 ratio) sequentially with 99 undiluted injectable drugs at room temperature. Each combination was prepared twice. One sample underwent a visual inspection and a light obstruction particle count test immediately after mixing. These tests were repeated on the other sample 4 hours after the initial mixing. To be considered compatible, the mixtures had to be free of precipitate or any other observable changes (turbidity, crystals, gas formation or color change) and had to meet the specification established by USP <788> 1.B, both at time zero and 4 hours after mixing.
Results: In all, 87 of the 99 injectable drugs tested with Plasmalyte-A® were found to be compatible both visually with the naked eye and with the particle counter, as per USP <788>.
Conclusion: A certain number of drugs were found to be compatible when mixed in a 1: 1 ratio with Plasmalyte-A®. However, it should be borne in mind that only the physical criteria were examined in this study.
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- 2021-04-06 (2)
- 2021-03-31 (1)
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